Anti-inflammatory

Retinoic acid
Catalog No: CFN90026

Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. It also helps repair Smad3/TGF-β1-induced lung damage in hyperoxic mice.

Picrinine
Catalog No: CFN98700

Picrinine has notable antitussive, antiasthmatic, expectorant, antiinflammatory and analgesic effects; medicinal composition containing picrinine as active ingredient can be prepared into multiple dosage forms and can be used for treating cold, fever, and respiratory disease caused by fever with good therapeutic effect, convenient application and high safety; picrinine can be used as quality index for pharmic control in preparing medicine for treating cold, fever and respiratory disease caused by fever.

Betulinic acid
Catalog No: CFN98706

Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, immunomodulatory, anti-inflammatory and anti-tumor properties.Betulinic acid is a selective inducer of apoptosis in tumor cells, it inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression induced by carcinogens and inflammatory stimuli.

Hydrocortisone
Catalog No: CFN90033

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. Hydrocortisone improves outcome by limiting this immunosuppressive feedback loop via an interleukin-10-dependent elimination of dendritic cell by natural killer cells. Chronic administration of hydrocortisone leads to deficits in certain tests of cognitive function sensitive to frontal lobe dysfunction and may contribute to the cognitive impairment reported in certain neuropsychiatric disorders. Hydrocortisone may reduce the extracellular spread of inflammation through the inhibition of matrix metalloproteinases.

Masticadienolic acid
Catalog No: CFN98707

Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic acid has anti-inflammatory activity, it shows effectiveness on the mouse ear inflammation induced by repeated applications of 12-0-tetradecanoylphorbol 13-acetate and on the phospholipase A2-induced foot paw edema.