Anti-inflammatory

Luteolin-7-O-glucoside
Catalog No: CFN98565

Luteolin-7-O-glucoside has cardioprotective, anti-asthmatic, anticancer, anti-inflammatory, and antioxidative activities, it can suppress leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells.Luteolin-7-O-glucoside modulated the Nrf2/MAPK/ PTEN/Akt /ERK/AP-1/PI3K-Akt signaling pathways, it suppressed the expression of β-catenin.

Cepharanthine
Catalog No: CFN98570

Cepharanthine has anti-plasmodial, anti-tumor , anti-inflammatory, antiallergic, antioxidant, and immunomodulatory activities in vivo, and it is a highly potent inhibitor of HIV-1 replication in a chronically infected monocytic cell line. Cepharanthine inhibits the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection.

Skullcapflavone I
Catalog No: CFN98643

Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I selectively induces apoptosis in T-HSC/Cl-6 cells via caspase-3 and caspase-9 activation.

Hirsutanonol
Catalog No: CFN98645

Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation. Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells, it also has chemoprotective effect on human lymphocytes DNA. Hirsutanonol or oregonin as an active ingredient composition for treating atopic dermatitis, hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.

Koaburaside
Catalog No: CFN98654

Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.