Anti-inflammatory

Cucurbitadienol
Catalog No: CFN92378

Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis. CYP87D18 catalyzed the oxidation of cucurbitadienol at C-11 to produce 11-oxo cucurbitadienol and 11-hydroxy cucurbitadienol.

Kaempferol 3-gentiobioside
Catalog No: CFN92384

Kaempferol 3-O-gentiobioside has antiinflammatory activity, shows weak inhibitory effects on Concanavalin A-induced histamine release, 5-lipoxygenase, and COX-1.

11-Deoxyalisol B
Catalog No: CFN92401

Reference standards.

Alisol F
Catalog No: CFN92402

Alisol F shows anti-inflammatory activities and liver protectionthrough the inhibition of MAPK, STAT3, and NF-κB activation in vitro and in vivo, it suppresses iNOS induction. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with the IC (50) value of 0.6 microM, and on HBV e antigen (HBeAg) secretion with the IC (50) value of 8.5 microM.

25-Anhydroalisol F
Catalog No: CFN92403

25-Anhydroalisol F shows anti-inflammatory activities and liver protection through the inhibition of MAPK, STAT3, and NF-κB activation in vitro and in vivo. It exhibits inhibitory effects on lipopolysaccharide-induced NO production in RAW 264.7 macrophage cells.