Anti-Atherosclerotic

Alisol A 23-acetate
Catalog No: CFN92544

Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways.

L-Arginine
Catalog No: CFN90550

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. L-Arginine exhibits anti-atherosclerotic effect, L-arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. Exogenous L-Arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway.

Notoginsenoside T5
Catalog No: CFN92824

Total panax notoginsenosides (TPNS) are the main active ingredients in San-Chi, the root of(Burk) F.H. Chen, which belongs to the Araliaceae family and has been used in traditional Chinese medicine to treat atherosclerosis;TPNS can prevent atherosclerosis by lowering serum lipid levels and regulating vascular CD40 and MMP-9 expression, TPNS may have implications for clinical treatment of atherosclerosis vascular disease.

Abietic acid
Catalog No: CFN90587

Abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.Abietic acid acts as a PPARα/γ dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-κB and the MAPK/AP-1 pathway and can be a useful agent for improving skin photoageing. Abietic acid can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis.

7Beta-Hydroxycholesterol
Catalog No: CFN90610

7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. 7beta-Hydroxycholesterol and 7-ketocholesterol have dual cytotoxic effects on the cells of the vascular wall by their ability to induce apoptosis in endothelial and smooth muscle cells and necrosis in fibroblasts. 7beta-Hydroxycholesterol can inhibit the proliferation of NCI-H460 cells through apoptosis via caspase activation. It can reinforce the susceptibility of K562 adriamycin-resistant cells to this drug, it also can enhance radiosensitivity in RDM4 cells.