Alisol A 23-acetate
Alisol A 23-acetate may possess therapeutic effects through their modulation of AR, PR, and GR pathways.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Hong Kong Baptist University2023, 048330T.
Analytical Methods2018, 10(27)
Pharmacognosy Journal2019, 11,6:1235-1241
Appl. Sci.2020, 10(5),1713.
Environ Toxicol.2023, tox.23999.
Metabolites2022, 12(6),507.
Plant Cell.2024, 158: 62.
Free Radic Biol Med.2021, 166:104-115.
Biochem Pharmacol.2017, 130:10-20
Front Pharmacol.2023, 14:1095083.
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Bioorg Med Chem Lett. 2014 Aug 1;24(15):3626-32.
Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists.[Pubmed:
24915879]
METHODS AND RESULTS:
Two triterpenes, alisol M 23-acetate and Alisol A 23-acetate from Alisma orientalis were determined whether they may act as androgen receptor (AR), progesterone receptor (PR), or glucocorticoid receptor (GR) modulators. Indeed, in the transient transfection reporter assays, alisol M 23-acetate and Alisol A 23-acetate transactivated AR in dose-dependent manner, while they transrepressed the transactivation effects exerted by agonist-activated PR and GR. Through molecular modeling docking studies, they were shown to respectively interact with AR, PR, or GR ligand binding pocket fairly well.
CONCLUSIONS:
All these results indicate that alisol M 23-acetate and Alisol A 23-acetate from Alisma orientalis might possess therapeutic effects through their modulation of AR, PR, and GR pathways.
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