Angiogenesis

Epicatechin
Catalog No: CFN98781

(−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has antinociceptive, insulin mimic actions and improves heart health; it has the potential to increase CREB-regulated gene expression and increase GluR2 levels and thus modulate neurotransmission, plasticity and synaptogenesis. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM; it inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

8-O-Acetylshanzhiside methyl ester
Catalog No: CFN98966

8-O-Acetylshanzhiside methyl ester(ND01) has potential against cerebral ischemic injury and experimental myocardial ischemia injury, it can increase angiogenesis and improve functional recovery after stroke. ND01 protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.

Vaccarin
Catalog No: CFN90131

Vaccarin exhibits extensive biological activities including vascular endothelial cell protective effects, it can significantly promote neovascularization by enhancing protein expression of p-Akt , p‑Erk, and CD31, and selectively protect vascular endothelium from dysfunction induced by H2O2.

Norviburtinal
Catalog No: CFN97411

Norviburtinal possesses novel angiogenesis effect. Norviburtinal and isopinnatal show in vitro cytotoxicity against cancer cell lines, norviburtinal has little selectivity for melanoma cell lines whilst isopinnatal also shows some cytotoxic activity.

Sarcosine
Catalog No: CFN90603

Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist, it preconditioning induces ischemic tolerance against global cerebral ischemia and this neuroprotective state is associated with changes in glycine transport and reduction of NR2B-containing NMDAR expression.Sarcosine modulates endothelial cell function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway.