Tryptanthrine
Tryptanthrin shows antimycobacterial and antifungal activity as well as anti-proliferative activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Planta Medica, 2012, 78(11):1284-1284.
Synthesis and determination of antimycobacterial activity of tryptanthrine, vasicine, vasicinone and derivatives thereof.[Reference:
WebLink]
METHODS AND RESULTS:
We describe the first application of the Niementowski quinazoline synthesis for the synthesis of vasicinone 3 (Fig.1), an alkaloid from Adhatoda vasica, a traditionally used plant in India for the treatment of respiratory diseases such as asthma and tuberculosis.
CONCLUSIONS:
This straightforward 2-step synthesis is an attractive basis for further medicinal chemistry work on vasicinone. Vasicine, vasicinone, deoxyvasicinone and deoxyvasicine were tested against Mycobacterium vaccae, a non-pathogenic mycobacterium closely related to Mycobacterium tuberculosis. Tryptanthrin, a related indoloquinazolinone from Strobilanthes cusia, showed antimycobacterial and antifungal activity as well as anti-proliferative activity.
