Dihydroxyfumaric acid
Dihydroxyfumaric acid can induce lipid peroxidation in rat liver microsomes.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Dihydroxyfumaric acid induced lipid peroxidation in rat liver microsomes.[Reference:
WebLink]
Dihydroxyfumaric acid induced lipid peroxidation in rat liver microsomes.
METHODS AND RESULTS:
This reaction was heat-insensitive contrary to the mitochondrial peroxidation reported in the previous paper, and was enhanced by p-chloromercuribenzoate. Additions of Fe2+ and Fe3+ stimulated both the lipid peroxidation and the disappearance of Dihydroxyfumaric acid. On the other hand, addition of Mn2+ or Cu2+, which stimulated the disappearance of Dihydroxyfumaric acid, inhibited the lipid peroxidation.
CONCLUSIONS:
Hydroxyl radical scavengers, superoxide dismutase and catalase had no effect on this lipid peroxidation and Dihydroxyfumaric acid disappearance. The cytochrome p-450 content decreased about 70 % in parallel with the lipid peroxidation.
