Neurotoxin

Janolusimide
Catalog No: CFN00120

Janolusimide is a neurotoxin and atropine antagonist.

Lactacystin
Catalog No: CFN00121

Lactacystin is a selective UPS inhibitor recently used to destroy dopamine (DA) neurons in animal models of Parkinson's disease (PD); marked differences in the rotational response to apomorphine and l-DOPA suggest different mechanisms of neurodegeneration evoked by Lactacystin and 6-OHDA. Lactacystin induces cell death and α-synuclein-positive inclusions in cytoplasm, it has diversified killing effects on gastric cancer cells, the mechanism may be related to induce the apoptosis by downregulation of nuclear factor kappa B viability.

Trichodesmine
Catalog No: CFN00433

Trichodesmine has greater lethality and neurotoxicity than monocrotaline, because of the two structural characteristics:(a) steric hindrance at position 14 of dehydroTrichodesmine results in greater resistance to hydrolysis, allowing more to be released from the liver and to be delivered to the brain;(b) the larger isopropyl substituent at position 14 of dehydroTrichodesmine renders the molecule more lipophilic, leading to greater penetration of the brain.

Dencichin
Catalog No: CFN90413

Dencichine is a haemostatic agent present, it is also a reported neurotoxic agent found in Lathyrus sativus (grass pea seed).

Dihydrorotenone
Catalog No: CFN90585

Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. It induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway.