Metal-chelators

1,2-Didehydrotanshinone IIA
Catalog No: CFN92165

1,2-Didehydrotanshinone IIA shows inhibitory effects against acetyl- (AChE) and butyrylcholinesterase (BChE). It also possesses metal-chelation capacity.

Miltipolone
Catalog No: CFN92250

Miltipolone is a good and broad-spectrum inhibitor against the growth of cancer cells. It also possibly acts as a Fe(2+) chelator to conduct its inhibitory activity.

Chebulanin
Catalog No: CFN92294

Chebulanin is a topoisomerase I inhibitor, it inhibits the calcineurin pathway in C. neoformans. Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. Chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis, it suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice.Chebulanin has anti-cancer acrtivity, it has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line.

Hypocrellin A
Catalog No: CFN92439

Hypocrellin A, an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex. Hypocrellin A has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory effects on MHC-restricted presentation of antigen.

Thonningianin A
Catalog No: CFN90633

Thonningianin A represents a new potent glutathione S-transferase in vitro inhibitor. Thonningianin A has anti-cancer and antioxidant properties, involves radical scavenging, anti-superoxide formation and metal chelation.