Hepatoprotective

Reynosin
Catalog No: CFN98344

Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α-synuclein protein expression. Reynosin exhibits a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM. Reynosin also has strong anti-mycobactericidal activity, with a minimal bactericidal concentration (MBC) of 128ug/mL against the H37Rv, 366-2009 and 104-2010 Mtb strains and a minimal inhibitory concentration (MIC) of 64, 64, 128, 128 and 128ug/mL against the H37Rv, 104-2010, 63-2009, 366-2009 and 430-2010 Mtb strains, respectively.

Byakangelicol
Catalog No: CFN98167

Byakangelicol exhibits hepatoprotective activities on tacrine-induced cytotoxicity in Hep G2 cells, with EC(50) values of 112.7 +/- 5.35 microM. Byakangelicol may have therapeutic potential as an anti-inflammatory drug on airway inflammation, it can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expression and the activity of COX-2 enzyme, it also can inhibit P-gp expressed. Byakangelicol shows a significant inhibition on the proliferation of cultured human tumor cells.

Secoisolariciresinol
Catalog No: CFN98363

Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. Secoisolariciresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. (-)-Secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids.

Astilbin
Catalog No: CFN98371

Astilbin has insecticidal, antioxidant, antibacterial, and anti-inflammatory activities, it may act as an efficient therapeutic agent for arthritis like cyclosporine A but with less toxicity, its mechanism includes a selective suppression on lymphocyte functions via reducing MMP and NO production. Astilbin can exert an early renal protective role to diabetic nephropathy (DN), inhibit production of transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF).Astilbin also alleviates contact hypersensitivity through a unique mechanism involving a negative cytokine regulation through stimulating IL-10, which is distinct from the immunosuppressant cyclosporin A.

4-Methoxycinnamic acid
Catalog No: CFN98191

4-Methoxycinnamic acid is a photosensitive compound, it shows various pharmacologic actions such as anti-cancer, hepatoprotective and antihyperglycemic activities, it also can stimulate insulin secretion from pancreatic β-cells by increasing Ca2+ influx via the L-type Ca2+ channels, but not through the closure of ATP-sensitive K+ channels. 4-Methoxycinnamic acid can strongly inhibit the diphenolase activity of mushroom tyrosinase, with the IC 50 value of 0.42 mM, and the inhibition is reversible.