L-Nicotine
Catalog No: CFN99512
Nicotine is a potent inhibitor of cardiac A-type K+ channels, with blockade probably due to block of closed and open channels, this action may contribute to the ability of nicotine to affect cardiac electrophysiology and induce arrhythmias.Nicotine is able to activate mitogenic signalling pathways, which promote cell growth or survival as well as increase chemoresistance of cancer cells, nicotine activates its downstream signalling to interfere with the ubiquitination process and prevent Bcl-2 from being degraded in lung cancer cells, resulting in the increase of chemoresistance.