Antioxidants

Betulin
Catalog No: CFN98710

Betulin (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line. Betulin has hypoglycemic, antineoplastic, anti-HIV, antimalarial and anti-inflammatory activities. Betulin can improve hyperlipidemia and insulin resistance and reduce atherosclerotic plaques. Betulin inhibits pro-inflammatory cytokines expression and NF-κB signaling activation through STAT3 signaling, it is associated with activation of AMP kinase and inhibition of mTOR/p70S6K/pS6 signaling in these cells.

Ellagic acid
Catalog No: CFN98716

Ellagic acid is a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. Ellagic acid has anti-inflammatory, antiproliferative and antioxidant properties, it can prevent cognitive and LTP deficits and also prevent brain inflammation following TBI. Ellagic acid reduced the expression of NO, MDA, IL-1β, TNF-α, COX-2 and NF-κB, and induced the production of GSH and IL-10.

Melatonin
Catalog No: CFN90037

Melatonin, a hormone produced in the brain, is a potent melatonin receptor activator, and possesses important anti-cancer, antioxidative and anti-inflammatory properties, it can reduce lead toxicity in vivo and in vitro. Melatonin may be useful as a pharmacological agent to protect against hepatic metabolic diseases due to its ability to regulate expression of miR-23a.

Boldine
Catalog No: CFN98718

Boldine displays anti-cancer, cytoprotective , anti-oxidant and anti-inflammatory activities. Boldine reduces oxidative stress and improves endothelium-dependent relaxation in aortas of diabetic mice largely through inhibiting ROS overproduction associated with Ang II-mediated BMP4-dependent mechanisms. Boldine may attenuate the catecholamine oxidation-induced brain mitochondrial dysfunction and decrease the dopamine-induced death of PC12 cells through a scavenging action on reactive oxygen species and inhibition of melanin formation and thiol oxidation.

Dehydrocostus lactone
Catalog No: CFN98720

Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ, Wnt/β-catenin activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. DHE has anti-inflammatory, antioxidant, anti-ulcer, immunomodulatory and anti-tumor properties, it can against osteoblast damage induced by AMA and cervical cancer. DHE exhibits strong larvicidal activity against A. albopictus with LC(50) values of 2.34 ug/ml.