Antihyperglycemic

Marein
Catalog No: CFN90851

Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy. Marein can improve insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein shows antioxidant activity, it shows Histone deacetylase enzymes (HDACs) inhibitory activity and it also can inhibit TNFα-induced NF-κB activation.

Desoxyrhapontigenin
Catalog No: CFN90854

Desoxyrhapontigenin has significant hypoglycemic, anti-inflammatory, and antioxidant effects, it shows inhibition of iNOS and COX-2 expression via the down-regulation of the MAPK signaling pathways and the inhibition of NF-κB and Akt activation. Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1(HO-1) expression in macrophages and inflammatory lung injury, and HO-1 is an important anti-inflammatory, antioxidative and cytoprotective enzyme. Desoxyrhapontigenin shows significant monoamine oxidase inhibitory activities with the IC50 value of 11.5 ± 1.1 uM.

Borapetoside E
Catalog No: CFN96274

Borapetoside E has anti-hyperglycemic activity, it can significantly reduce serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice.

Octadecyl caffeate
Catalog No: CFN96314

z-Octadecyl caffeate may have pain-relieving activity. Octadecyl caffeate and coptisonine can stimulate glucose uptake at 25 and 50 ug/mL. Octadecyl caffeate and octadecyl coumarate applied to the surface of susceptible varieties in laboratory bioassays reduced feeding and oviposition, as observed on roots of resistant varieties, and therefore are implicated in weevil resistance.