Antifungal

Ferruginol
Catalog No: CFN92178

Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells. Ferruginol has antimicrobial and antifungal activities against wood-rot fungi (basidiomycetes), can cause cellular dysfunction and damage, lead to growth inhibition and autophagic cell death of fungi.

6,7-Dehydroferruginol
Catalog No: CFN92246

6,7-Dehydroferruginol has potent activity against F. palustris . 6,7-Dehydroferruginol and sugiol are weakly active against Heterosigma akashiwo.

(-)-Pinoresinol
Catalog No: CFN92287

Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels; PIN can ameliorate CCl4-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1. (+)-Pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.

Licoflavone C
Catalog No: CFN92289

Licoflavone C has cytotoxic, and antioxidative effects, it has protective effect toward the chromosome damage induced by DAU or MMC in cultured human peripheral lymphocytes. Licoflavone C exhibits a dose-dependent antagonistic activity at concentrations up to 10−4 M, but stimulates β-galactosidase expression at higher concentrations resulting in a U-shaped-like dose-response curve.

Chebulanin
Catalog No: CFN92294

Chebulanin is a topoisomerase I inhibitor, it inhibits the calcineurin pathway in C. neoformans. Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. Chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis, it suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice.Chebulanin has anti-cancer acrtivity, it has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line.