Antifertility

Acetate gossypol
Catalog No: CFN98529

Acetate gossypol has antifertility action. Acetate gossypol is a potent inhibitor of Bcl-2 and Bcl-xl, it has significant antiproliferative and antiapoptotic effects on multiple myeloma cells in vitro and in vivo, it also has apoptosis-inducing activity in primary cultured leukemia cells.

Corticosterone
Catalog No: CFN90044

Corticosterone, the major stress hormone, is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid, it is cytotoxic toward neurons, and the cytotoxic effect could be protected by Yokukansan. A delayed effect of elevated Corticosterone on breeding success rather than an immediate suppression of prolactin concentrations causing premature failure.

Quassin
Catalog No: CFN97246

Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity. It also exhibits P. falciparum inhibitory activity (IC50=0.06 micro g/ml, 0.15 micro M). Quassin possesses anti-anaemic property, it can significantly increase red blood cell count, pack cell volume and haemoglobin concentration.

Demethylzeylasteral
Catalog No: CFN90136

Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7, and the inhibition kinetic parameters (Ki) are calculated to be 0.6 uM and 17.3 uM for UGT1A6 and UGT2B7, respectively. Demethylzeylasteral has antimicrobial, strong immunosuppressive, and antifertility activities; it concentration-dependently and in a partially reversible manner can inhibit the Ca(2+) current in spermatogenic cells with an IC(50) of 8.8 microg/ml, and it also can inhibit significantly the sperm acrosome reaction initiated by progesterone.

Grandiflorenic acid
Catalog No: CFN97781

Pure Grandiflorenic acid can reproduce the uterine responses induced by zoapatle leaves aqueous extract , suggests that grandiflorenic acid may have antifertility effect.