Anticancer

Oleandrin
Catalog No: CFN98693

Oleandrin has anticarcinogenic, anti-inflammatory, and growth-modulatory effects , which may thus be partially ascribed to the inhibition of activation of NF-κB and AP-1 and potentiation of apoptosis; it has stronger anti-proliferative activity in undifferentiated CaCO-2 cells (IC50, 8.25 nM) , causes an autophagic cell death and altered ERK phosphorylation in undifferentiated.Oleandrin inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.

Quinovic acid
Catalog No: CFN98694

Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by inducing apoptosis through modulation of NF-κB.

Hederagenin
Catalog No: CFN98695

Hederagenin shows anti-cancer,anti-inflammatory, antidepressant-like ,anticomplementary, and antimutagenic effects, it can evoke hemolysis on the erythrocytes, and has cytotoxic on various tumor cell lines, P-388, L-1210, U-937, HL-60, SNU-5 and HepG2. Hederagenin can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB, regulate monoamine neurotransmitters and 5-HTT mRNA expression.

Vitamin D3
Catalog No: CFN90027

Vitamin D3 is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM. Supplemental calcium and Vitamin D3 may increase TGFβ1 expression and shift TGFα expression downward from the differentiation to the proliferation zone in the crypts in the normal-appearing colorectal mucosa of sporadic colorectal adenoma patients.

alpha-Lapachone
Catalog No: CFN98702

alpha-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi. alpha-Lapachone is an "irreversible" inhibitor of topoisomerase II, it can inhibit initial non-covalent binding of topoisomerase II to DNA and, and can induce religation of DNA breaks (even in pre-established ternary complexes) before dissociating the enzyme from DNA.