Anti-photoaging

Columbianetin
Catalog No: CFN90185

Columbianetin is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. Columbianetin has anti-inflammatory effects, it promotes histamine release, and inhibits the histamine release by substance P, suggests that it may be helpful in regulating mast cell-mediated allergic inflammatory responses. (2'S)-columbianetin can be effectively used to protect keratinocytes from UVB induced damage.

6,8-Diprenylorobol
Catalog No: CFN97705

6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals; it is evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. 6,8-Diprenylorobol shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor (ER) antagonist. 6,8-Diprenylorobol shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also may be a possible candidate for the treatment of neurodegenerative diseases. 6,8-Diprenylorobol has antioxidant activity, it can reduce A2E photooxidation in a dose dependent manner.

Cycloheterophyllin
Catalog No: CFN97748

Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging. Cycloheterophyllin exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA).It also shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation, due to an inhibitory effect on cyclooxygenase.

20(R)-Ginsenoside Rh2
Catalog No: CFN90340

20(R)-Ginsenoside Rh2, a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory. 20(R)-Ginsenoside Rh2 has anticancer, anti- proliferation, anti-inflammatory and antioxidative activities, it also shows selective osteoclastgenesis inhibitory activity. 20(R)-Ginsenoside Rh2 reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells.

Eupalinolide B
Catalog No: CFN90382

Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Eupalinolide B and Eupalinolide A induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90, they could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.