Anti-osteoporosis

Furan-2-carboxylic acid
Catalog No: CFN97598

Furan-2-carboxylic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.Furan-2-carboxylic acid also has anti-bacterial effect, inhibits the proliferation of some slow-growing or difficult-to-culture bacteria on the plates.

Isotaxiresinol
Catalog No: CFN97771

Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol may be useful for treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency.

Tanshinol B
Catalog No: CFN90370

Reference standards.

8-Prenylnaringenin
Catalog No: CFN92016

8-Prenylnaringenin is a phytoestrogen with high estrogenic activity, it shows more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein. 8-Prenylnaringenin at all assayed doses (0.001-20 µM) presumably improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle.

2-Hydroxy-1-methoxyanthraquinone
Catalog No: CFN92111

2-Hydroxy-1-methoxy- anthraquinone has antiosteoporotic activity, it can promote osteoblast proliferation, and can inhibit osteoclast TRAP activity and bone resorption.