Anti-melanogenic

Intermedine
Catalog No: CFN00285

Intermedin (IMD), a multi-functional peptide, plays important roles in cardiovascular protection, the endogenous IMD and its receptor complexes are induced in hypertrophic cardiomyocytes and proposed to play an important role in the pathogenesis of cardiac hypertrophy. Intermedin can decrease the melanin content of the skin of Rana pipiens.

Xanthoxylin
Catalog No: CFN97465

Xanthoxyline has antispasmodic, fungistatic, antinociceptive and antioedematogenic activities. Xanthoxylin has inhibitory effect on blood platelet aggregation; it induces melanogenesis mainly via cAMP-mediated PKA activation, other signaling pathways may also play a role in xanthoxylin-induced melanogenesis.

Ohchinin
Catalog No: CFN97704

Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm).

Eupalinolide B
Catalog No: CFN90382

Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Eupalinolide B and Eupalinolide A induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90, they could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.

4-Methylumbelliferone
Catalog No: CFN90421

4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM, which has antitumoral and antimetastatic effects. 4-Methylumbelliferone may inhibit the phosphorylation of HAS2 by PKC through the stimulation of O-GlcNAcylation; it also similarly ameliorates hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels.