Anti-inflammatory

Eburicoic acid
Catalog No: CFN90414

Eburicoic acid and TR2 have anti-inflammatory activity, the mechanism is related to the decrease of inflammatory cytokines and an increase of antioxidant enzyme activity, they protect the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms. Eburicoic acid has significant anti-liver cancer effects and more distinctive mechanisms.

Tetrahydrocoptisine
Catalog No: CFN90416

Tetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways.Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression.

Amphotericin B
Catalog No: CFN90422

Amphotericin B is an antifungal agent. Amphotericin B can regulate inflammatory cytokines in host cells and regulate inflammatory responses in HGEC, it inhibits the A. actinomycetemcomitans-induced phosphorylation of ERK and p38 MAP kinase. Amphotericin B inhibits the A. actinomycetemcomitans-induced production of prostaglandin E2, the inhibition of the PKA signaling pathway can aid in reducing the degree of nephrotoxicity caused by Amphotericin B. Treatment with amphotericin B, particularly in combination with MCSF, increased the number of oligodendrocyte precursor cells and promoted remyelination within lesions.

Simvastatin
Catalog No: CFN90427

Simvastatin is an FDA-approved cholesterol-lowering medication, it possesses potent anti-inflammatory property and has potent benefits on endothelial and smooth muscle cell-mediated vasomotor responses. Simvastatin rescues Aβ-mediated cerebrovascular and cognitive deficits. Simvastatin reduces burn-induced splenic apoptosis via downregulation of the TNF-α/NF-κB pathway, it induces p65 instability leads to MMP-9 down-regulation in leukemia cells, while it induces JNK1/c-Jun/ATF-2 activation maintains the MMP-2 expression underlying p65 down-regulation.

Aloin B
Catalog No: CFN90434

Dietary supplementation of aloe components (aloin, aloesin and aloe-gel) can ameliorate intestinal inflammatory responses in a 3% dextran sulfate sodium (DSS)-induced ulcerative colitis rat model, in particular, aloesin is the most potent inhibitor. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation.