(-)-Chelidonine
(-)-Chelidonine is a natural product from Glaucium squamigerum KAR. et KIR.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Int J Mol Sci.2022, 23(5):2796.
Compounds.2023, 3(1), 169-179.
Phytofrontiers2024, 2690-5442.
BMC Microbiol.2019, 19(1):78
Pak J Pharm Sci.2019, 32(6)
Molecules.2019, 25(1):E103
Int J Mol Sci.2022, 23(21):13112.
Front Pharmacol.2021, 12:615157.
J Pharmaceutical and Biomedical Analysis2022, 114631.
Phytomedicine.2021, 84:153501.
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Collect. Czech. Chem. Commun. 1984, 49(5), 1318-1324.
Additional alkaloids from Glaucium squamigerum KAR. et KIR.[Reference:
WebLink]
METHODS AND RESULTS:
A new quaternary alkaloid, (-)-β-N-methylisocorypalminium hydroxide, was isolated from KAR. et KIR. in the form of iodide. In addition to the already known to occur in this plant, allocryptopine (the main alkaloid), protopine, chelerythrine, sanguinarine, corydine, coptisine and berberine, additional , (-)-Chelidonine, (±)-chelidonine (diphylline) and chelirubine were also isolated from the non-quaternary fraction, while from the fraction of quaternary (-)-β-N-methylcanadinium iodide (the second main alkaloid), (-)-α-N-methylcanadinium iodide and (-)-β-N-methylstylopinium iodide were isolated after conversion of the to iodides. Further the presence of small amounts of stylopine, canadine, scoulerine, corysamine, corytuberine, magnoflorine, α-N-methylstylopinium hydroxide and β-N-methyltetrahydropalmatinium hydroxide were also detected.
