Inhibitors

Abiraterone Acetate
Catalog No: CFN90022

Abiraterone acetate is a potent, selective, and orally available inhibitor of CYP17, the key enzyme in androgen and estrogen biosynthesis. It achieves sustained suppression of testosterone in both blood and bone marrow aspirate to less than picograms-per-milliliter levels. Abiraterone acetate shows antitumour activity against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100), it can significantly prolong overall survival in patients with metastatic castration-resistant prostate cancer who have progressed after docetaxel treatment.

Hederagonic acid
Catalog No: CFN98696

Hederagonic acid ,arjunolic acid, bayogenin, and 4-epi-hederagonic acid show moderate potency of glycogen phosphorylase inhibition with IC50 of 53-103 uM.

alpha-Lapachone
Catalog No: CFN98702

alpha-Lapachone has antineoplastic activity, it shows an approximately trypanocidal activity against Trypanosoma cruzi. alpha-Lapachone is an "irreversible" inhibitor of topoisomerase II, it can inhibit initial non-covalent binding of topoisomerase II to DNA and, and can induce religation of DNA breaks (even in pre-established ternary complexes) before dissociating the enzyme from DNA.

Atraric acid
Catalog No: CFN98703

Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of prostatic diseases. It inhibits PTP1B activity in a dose-dependent manner with IC50 values of 51.5 uM, suggest that atraric acid has potential to treat diabetes.

Masticadienolic acid
Catalog No: CFN98707

Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic acid has anti-inflammatory activity, it shows effectiveness on the mouse ear inflammation induced by repeated applications of 12-0-tetradecanoylphorbol 13-acetate and on the phospholipase A2-induced foot paw edema.