Anticancer

Eupalinolide A
Catalog No: CFN90381

Eupalinolide A and Eupalinolide B induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. They could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.

Jaceosidin
Catalog No: CFN90386

Jaceosidin has immunosuppressive, anti-oxidative, anti-inflammatory, and anticancer activities, it is also a microglial inhibitor with anti-neuroinflammation activity. Jaceosidin modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin inhibits T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway.

Napellonine
Catalog No: CFN90393

Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

Vincristine sulfate
Catalog No: CFN90400

Vincristine sulfate is an antitumor vinca alkaloid which inhibits microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds to microtubule with a Ki of 85 nM.

Vinorelbine
Catalog No: CFN90401

Vinorelbine is a semi-synthetic Vinca alkaloid which is currently used in treatment of different cancer types mainly advanced breast cancer (ABC) and advanced/metastatic non-small cell lung cancer (NSCLC). Vinorelbine-loaded SSM can be developed as a new, safe, stable, and effective nanomedicine for the treatment of breast and lung cancers.