Anti-inflammatory

Geniposide
Catalog No: CFN98261

Geniposide exhibits anti-diabetic, antidepressant-like, antioxidative, anti-apoptotic, antiproliferative and neuroprotective activities. Geniposide is an agonist for GLP-1 receptor, it regulates expression of anti-oxidative proteins including HO-1 and Bcl-2 by activating the transcriptor of p90RSK via MAPK signaling pathway in PC12 cells. Geniposide may suppress TGF-β1-induced EMT in hepatic fibrosis by inhibiting the TGFβ/Smad and ERK-mitogen-activated protein kinase (MAPK) signaling pathways.

3-Geranyl-4-methoxybenzoic acid
Catalog No: CFN98266

3-Geranyl-4-methoxybenzoic acid exhibits stronger inhibition effect on the activation of hyaluronidase than that of tranilast.

(-)-Epiafzelechin
Catalog No: CFN98271

(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epicatechin shows zero and/or the lowest activities against pancreatic lipase (IC50 > 20 microM). Epiafzelechin has antioxidant properties.

L-Menthol
Catalog No: CFN98123

Menthol is used in analgesic balms and also in foods and oral hygiene products for its fresh cooling sensation, menthol enhances cooling by interacting with the cold-sensitive thermoTRP channel TRPM8. L-Menthol has antiperistaltic and anti-inflammatory effects, clinical trials investigating the potential therapeutic efficacy of L-menthol for treatment of chronic inflammatory disorders such as bronchial asthma, colitis and allergic rhinitis seem worthwhile, it sprayed on the gastric mucosa significantly suppresses peristalsis with minimal adverse drug reactions during upper GI endoscopy.

Dauricine
Catalog No: CFN98129

Dauricine may has neuroprotective, and anti-tumor effects, it can pass the blood‑brain barrier, and that P‑glycoprotein has an important role in the transportation of Dauricine across the blood‑brain barrier, it can inhibit tumor cells in urinary system and colon cancer cell proliferation, invasion; induce cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. Dauricine also has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A.